Jerome's Latin Vulgate mistranslated "mystery" (mysterion) as "sacrament" in Ephesians 5:32, contributing to the Roman Catholic doctrine of marriage as a sacrament.

Winger cannot give a comprehensive answer but identifies one documented case: Ephesians 5:32 uses the Greek word for mystery (mysterion) in the context of marriage as a picture of Christ and the church. Jerome translated this as "sacramentum." Over centuries this contributed to the Roman Catholic Church formally designating marriage as one of the seven sacraments. The Council of Trent affirmed the Latin Vulgate as the official Bible of the Roman Catholic Church, in contrast to the Reformation cry to return to original Greek and Hebrew sources. Winger does not claim Jerome corrupted the gospel itself.