Don

Mar 10:6 But from the beginning of creation, ‘God made them male and female.’

We know that this was not on day 1, 2, 3, 4, or 5 in the creation account of Gen 1.

Mat 19:4 He answered, “Have you not read that he who created them from the beginning made them male and female,

So Mat 19:4 and Mar 10:6 are saying the same thing in different ways.
They are both speaking about the time of origins and saying in this period of time, God “made” them male and female.