Don

Ishah (woman) coming out of ish (man) is a wordplay, as “ah” is a normal hebrew way of feminizing something, so the man is saying that she is a female man, like him in many ways but unlike him in her femaleness.

The whole sentence is also a “Wowie Zowie” statement, recall the man had gone thru all the animals naming them and not finding a partner.  When he finally sees her, “Wowie Zowie” was appropriate.