TL

This does give us pause as to what influences a passion for something, even something good. What constitutes a call for God, is the secondary question.

Not all instances of spousal disagreement necessarily should squelch a passion or calling IMO. However, in the instance of missionary work, which IMO is not a type of spiritual gift but merely one exercise of a spiritual gift, I think a spouse would absolutely need to be in agreement. There are many things we can be called to that we can do without jeopardizing the welfare of our families.